Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease
Identifieur interne : 001146 ( Main/Exploration ); précédent : 001145; suivant : 001147Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease
Auteurs : Monika Pötter-Nerger [Allemagne] ; Martin M. Reich [Allemagne] ; James G. Colebatch [Australie] ; G. Deuschl [Allemagne] ; Jens Volkmann [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.
Affiliations:
- Allemagne, Australie
- Bavière, District de Basse-Franconie, Schleswig-Holstein
- Kiel, Sydney, Wurtzbourg
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000090
- to stream PascalFrancis, to step Curation: 002C24
- to stream PascalFrancis, to step Checkpoint: 000219
- to stream Main, to step Merge: 001198
- to stream Main, to step Curation: 001146
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease</title><author><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Reich, Martin M" sort="Reich, Martin M" uniqKey="Reich M" first="Martin M." last="Reich">Martin M. Reich</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Colebatch, James G" sort="Colebatch, James G" uniqKey="Colebatch J" first="James G." last="Colebatch">James G. Colebatch</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Prince of Wales Clinical School and Medical Research Institute, University New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G." last="Deuschl">G. Deuschl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Julius-Maximilian- University</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0369636</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0369636 INIST</idno><idno type="RBID">Pascal:12-0369636</idno><idno type="wicri:Area/PascalFrancis/Corpus">000090</idno><idno type="wicri:Area/PascalFrancis/Curation">002C24</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000219</idno><idno type="wicri:doubleKey">0885-3185:2012:Potter Nerger M:differential:effect:of</idno><idno type="wicri:Area/Main/Merge">001198</idno><idno type="wicri:Area/Main/Curation">001146</idno><idno type="wicri:Area/Main/Exploration">001146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease</title><author><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Reich, Martin M" sort="Reich, Martin M" uniqKey="Reich M" first="Martin M." last="Reich">Martin M. Reich</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Colebatch, James G" sort="Colebatch, James G" uniqKey="Colebatch J" first="James G." last="Colebatch">James G. Colebatch</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Prince of Wales Clinical School and Medical Research Institute, University New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G." last="Deuschl">G. Deuschl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrecht-University</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Julius-Maximilian- University</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopa</term><term>Evoked potential</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Reflex</term><term>Vestibular syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome vestibulaire</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Dopa</term><term>Potentiel évoqué</term><term>Réflexe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li></country><region><li>Bavière</li><li>District de Basse-Franconie</li><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li><li>Sydney</li><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name></region><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G." last="Deuschl">G. Deuschl</name><name sortKey="Reich, Martin M" sort="Reich, Martin M" uniqKey="Reich M" first="Martin M." last="Reich">Martin M. Reich</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country><country name="Australie"><noRegion><name sortKey="Colebatch, James G" sort="Colebatch, James G" uniqKey="Colebatch J" first="James G." last="Colebatch">James G. Colebatch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001146 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001146 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0369636
|texte= Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease
}}
| This area was generated with Dilib version V0.6.23. |  |